Global Cellular Metabolic Rewiring Adapts Corynebacterium glutamicum to Efficient Nonnatural Xylose Utilization

Author:

Sun Xi123,Mao Yufeng4,Luo Jiahao123,Liu Pi4,Jiang Meiru123,He Guimei123,Zhang Zhidan4,Cao Qichen4,Shen Jie4,Ma Hongwu4,Chen Tao123,Wang Zhiwen123ORCID

Affiliation:

1. Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, China

2. Frontier Science Center for Synthetic Biology (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, China

3. Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China

4. Biodesign Center, Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

Abstract

A novel xylose regulatory mechanism mediated by the transcription factor IpsA was revealed. A synergistic effect on carbon metabolism and energy supply was found to endow C. glutamicum with the efficient xylose utilization and rapid growth phenotype.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Tianjin City

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Reference59 articles.

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