In Vivo Reversion to the Wild-Type β-Lactam Resistance Phenotype Mediated by a Plasmid Carrying ampR and qnrA1 in Enterobacter cloacae-Reference-Cited by-同舟云学术

In Vivo Reversion to the Wild-Type β-Lactam Resistance Phenotype Mediated by a Plasmid Carrying ampR and qnrA1 in Enterobacter cloacae

Published:2006-09 Issue:9 Volume:50 Page:3175-3178
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

González-López J. J.¹,Sabaté M.¹,Lavilla S.¹,Larrosa M. N.¹,Bartolomé R. M.¹,Prats G.¹

Affiliation:

1. Servicio de Microbiología, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain

Abstract

ABSTRACT Resistance to β-lactams and quinolones in two isogenic Enterobacter cloacae isolates was studied. One was susceptible to cefoxitin and amoxicillin-clavulanate. The other one showed its natural β-lactam resistance pattern. Both isolates had a nonfunctional AmpR regulator. However, within the second one, the presence of a plasmid carrying ampR and qnrA1 allowed reversion to the wild-type β-lactam resistance phenotype and decreased susceptibility to fluoroquinolones.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00273-06

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