Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses-Reference-Cited by-同舟云学术

Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses

Published:2020-11-17 Issue:12 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cagno Valeria¹,Gasbarri Matteo²,Medaglia Chiara¹,Gomes Diana³,Clement Sophie⁴,Stellacci Francesco²,Tapparel Caroline¹^ORCID

Affiliation:

1. Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland

2. Institute of Materials, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

3. Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland

4. Division of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland

Abstract

Viral infections are among the main causes of death worldwide, and we lack antivirals for the majority of viruses. Heparin-like sulfated or sulfonated compounds have been known for decades for their ability to prevent infection by heparan sulfate proteoglycan (HSPG)-dependent viruses but only in a reversible way. We have previously shown that gold nanoparticles and β-cyclodextrins coated with mercapto-undecane sulfonic acid (MUS) inhibit HSPG-dependent viruses irreversibly while retaining the low-toxicity profile of most heparin-like compounds.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02001-20

Reference17 articles.

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