Structural Insights into Ceftobiprole Inhibition of Pseudomonas aeruginosa Penicillin-Binding Protein 3-Reference-Cited by-同舟云学术

Structural Insights into Ceftobiprole Inhibition of Pseudomonas aeruginosa Penicillin-Binding Protein 3

Published:2020-04-21 Issue:5 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kumar Vijay¹^ORCID,Tang Christie¹,Bethel Christopher R.²,Papp-Wallace Krisztina M.²³⁴^ORCID,Wyatt Jacob¹,Desarbre Eric⁵,Bonomo Robert A.¹²³⁴⁶,van den Akker Focco¹

Affiliation:

1. Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA

2. Louis Stokes Cleveland Veterans Affairs Medical Center Research Service, Cleveland, Ohio, USA

3. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

4. Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA

5. Basilea Pharmaceutica International Ltd., Basel, Switzerland

6. Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA

Abstract

Ceftobiprole is an advanced-generation broad-spectrum cephalosporin antibiotic with potent and rapid bactericidal activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus , as well as susceptible Gram-negative pathogens, including Pseudomonas sp. pathogens. In the case of Pseudomonas aeruginosa , ceftobiprole acts by inhibiting P. aeruginosa penicillin-binding protein 3 (PBP3). Structural studies were pursued to elucidate the molecular details of this PBP inhibition.

Funder

U.S. Department of Veterans Affairs

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00106-20

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