Spread of a Low-Fitness Drug-Resistant Mycobacterium tuberculosis Strain in a Setting of High Human Immunodeficiency Virus Prevalence-Reference-Cited by-同舟云学术

Spread of a Low-Fitness Drug-Resistant Mycobacterium tuberculosis Strain in a Setting of High Human Immunodeficiency Virus Prevalence

Published:2008-04 Issue:4 Volume:46 Page:1514-1516
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Strauss O. J.¹,Warren R. M.¹,Jordaan A.¹,Streicher E. M.¹,Hanekom M.¹,Falmer A. A.¹,Albert H.²,Trollip A.²,Hoosain E.³,van Helden P. D.¹,Victor T. C.¹

Affiliation:

1. DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, Western Cape, South Africa

2. Biotec Laboratories, Ltd., c/o National Health Laboratory Service, Cape Town, Western Cape, South Africa

3. Nelson Mandela Metropolitan Municipality, Port Elizabeth, Eastern Cape, South Africa

Abstract

ABSTRACT The fitness cost associated with the evolution of resistance to rifampin in Mycobacterium tuberculosis may be different in clinical isolates compared to in vitro-generated mutants. An atypical Beijing strain (attenuated phenotype) demonstrated the ability to spread despite acquiring resistance to rifampin. Transmission was linked to human immunodeficiency virus coinfection ( P = 0.029), raising concern for the spread of drug resistance in vulnerable populations.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01938-07

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