A Test for the Rapid Detection of the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus

Author:

Rincon Sandra1,Carvajal Lina P.1,Gomez-Villegas Sara I.2,Echeverri Aura M.1,Rios Rafael1,Dinh An2,Pedroza Claudia3,Ordoñez Karen M.45,Nannini Esteban67,Sun Zhizeng8,Fowler Vance G.9,Murray Barbara E.21011,Miller William R.210ORCID,Palzkill Timothy8ORCID,Diaz Lorena1,Arias Cesar A.2101112,Reyes Jinnethe1ORCID

Affiliation:

1. Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia

2. Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA

3. Center for Clinical Research and Evidence-Based Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA

4. E.S.E. Hospital Universitario San Jorge de Pereira, Risaralda, Colombia

5. Universidad Tecnológica de Pereira, Risaralda, Colombia

6. Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina

7. Instituto de Inmunología Clínica y Experimental de Rosario, CONICET, Rosario, Argentina

8. Baylor College of Medicine, Houston, Texas, USA

9. Division of Infectious Diseases, Department of Medicine, Duke University, Durham, North Carolina, USA

10. Division of Infectious Diseases, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA

11. Department of Microbiology and Molecular Genetics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA

12. Center for Infectious Diseases, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA

Abstract

The cefazolin inoculum effect (CzIE) has been associated with therapeutic failures and mortality in invasive methicillin-susceptible Staphylococcus aureus (MSSA) infections. A diagnostic test to detect the CzIE is not currently available.

Funder

Departamento Administrativo de Ciencia, Tecnología e Innovación

HHS | NIH | National Institute of Allergy and Infectious Diseases

University of Texas Health Science Center at Houston

University of Texas System

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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