Author:
Colaizzi P A,Polk R E,Poynor W J,Raffalovich A C,Cefali E A,Beightol L A
Abstract
The single-dose pharmacokinetics of azlocillin and piperacillin were compared by using a randomized, crossover design. The concentrations of azlocillin in serum were consistently higher than those of piperacillin throughout an 8-h study. The area under the time-concentration curve of azlocillin was significantly greater than that of piperacillin, and the total body clearance of azlocillin was significantly lower than that of piperacillin.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference19 articles.
1. Piperacillin kinetics;Batra V. K.;Clin. Pharmacol. Ther.,1979
2. Overview of acylureidopenicillin pharmacokinetics;Bergan T.;Scand. J. Infect. Dis.,1982
3. Review of the pharmacokinetics and dose dependency of azlocillin in normal subjects and patients with renal insufficiency;Bergan T.;J. Antimicrob. Chemother. Il(Suppl. B):101-114.,1983
4. Dose dependence of piperacillin pharmacokinetics;Bergan T.;Chemotherapy (Basel),1982
5. High-performance liquid chromatographic determination of piperacillin in plasma;Brisson A. M.;Antimicrob. Agents Chemother.,1982
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