Porcine Reproductive and Respiratory Syndrome Virus: Description of Persistence in Individual Pigs upon Experimental Infection-Reference-Cited by-同舟云学术

Porcine Reproductive and Respiratory Syndrome Virus: Description of Persistence in Individual Pigs upon Experimental Infection

Published:2000-11-15 Issue:22 Volume:74 Page:10834-10837
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Allende R.¹,Laegreid W. W.²,Kutish G. F.³,Galeota J. A.¹,Wills R. W.¹,Osorio F. A.¹

Affiliation:

1. Department of Veterinary and Biomedical Sciences, University of Nebraska—Lincoln, Lincoln, Nebraska 68583-09051;

2. U.S. Meat Animal Research Center, U.S. Department of Agriculture/Agricultural Research Service, Clay Center, Nebraska 689332; and

3. Plum Island Animal Disease Center, U.S. Department of Agriculture/ Agricultural Research Service, Greenport, New York 119443

Abstract

ABSTRACT We studied the persistence of porcine reproductive and respiratory syndrome virus (PRRSV) in individual experimentally infected pigs, during a period of up to 150 days postinfection (dpi). The results of this study suggest that the persistence of PRRSV involves continuous viral replication but that it is not a true steady-state persistent infection. The virus eventually clears the body and seems to do it in most of the animals by 150 dpi or shortly thereafter. High genetic stability was seen for several regions of the persistent PRRSV's genome, although some consistent mutations in the genes of envelope glycoproteins and M protein were also observed.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.22.10834-10837.2000

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