The Genomic RNA in Ty1 Virus-Like Particles Is Dimeric-Reference-Cited by-同舟云学术

The Genomic RNA in Ty1 Virus-Like Particles Is Dimeric

Published:2000-11-15 Issue:22 Volume:74 Page:10819-10821
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Feng Ya-Xiong¹,Moore Sharon P.²,Garfinkel David J.²,Rein Alan¹

Affiliation:

1. HIV Drug Resistance Program1 and

2. Gene Regulation and Chromosome Biology Laboratory,2 National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland

Abstract

ABSTRACT The yeast retrotransposon Ty1 resembles retroviruses in a number of important respects but also shows several fundamental differences from them. We now report that, as in retroviruses, the genomic RNA in Ty1 virus-like particles is dimeric. The Ty1 dimers also resemble retroviral dimers in that they are stabilized during the proteolytic maturation of the particle. The stabilization of the dimer suggests that one of the cleavage products of TyA1 possesses nucleic acid chaperone activity.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.22.10819-10821.2000

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