Microbial Formation of 4-Thiouracil

Author:

Dolak L.1,Sokolski W. T.1,Mizsak S.1,Stroman D. W.1,Sebek O. K.1

Affiliation:

1. The Upjohn Research Laboratories, Kalamazoo, Michigan 49001

Abstract

A soil organism identified as Streptomyces libani var. soldani was found to produce 4-thiouracil. The product was isolated in a yield of 150 μg/ml of filtered beer and characterized by C-13 magnetic resonance and high-resolution mass spectroscopy. The product has a broad antibacterial spectrum but low specific activity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference5 articles.

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4. The isolation of 4-thiouridylic acid from the soluble ribonucleic acid ofEscherichia coli;Lipsett M. N.;J. Biol. Chem.,1965

5. Researches on pyrimidines. XL. The thio derivatives of uracil and the preparation of uracil in quantity;Wheeler H. L.;Am. Chem. J.,1908

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