Biochemical and Structural Basis of Triclosan Resistance in a Novel Enoyl-Acyl Carrier Protein Reductase-Reference-Cited by-同舟云学术

Biochemical and Structural Basis of Triclosan Resistance in a Novel Enoyl-Acyl Carrier Protein Reductase

Published:2018-08 Issue:8 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Khan Raees¹,Zeb Amir²,Roy Nazish¹,Thapa Magar Roniya¹,Kim Hyo Jeong¹,Lee Keun Woo²,Lee Seon-Woo¹

Affiliation:

1. Department of Applied Bioscience, Dong-A University, Busan, Republic of Korea

2. Division of Applied Life Science (BK21 Plus Program), Plant Molecular Biology and Biotechnology Research Center, Research Institute of Natural Science, Gyeongsang National University, Jinju, Republic of Korea

Abstract

Enoyl-acyl carrier protein reductases (ENR), such as FabI, FabL, FabK, and FabV, catalyze the last reduction step in bacterial type II fatty acid biosynthesis. Previously, we reported metagenome-derived ENR homologs resistant to triclosan (TCL) and highly similar to 7-α hydroxysteroid dehydrogenase (7-AHSDH).

Funder

Rural Development Administration

National Research Foundation of Korea

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00648-18

Reference52 articles.

1. Diversity in enoyl-acyl carrier protein reductases

2. Acetoacetyl-acyl carrier protein synthase