Effect of Simvastatin, an Established Lipid-Lowering Drug, on Pulmonary Chlamydia pneumoniae Infection in Mice-Reference-Cited by-同舟云学术

Effect of Simvastatin, an Established Lipid-Lowering Drug, on Pulmonary Chlamydia pneumoniae Infection in Mice

Published:2005-09 Issue:9 Volume:49 Page:3959-3962
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Erkkilä Leena¹,Jauhiainen Matti²,Laitinen Kirsi³,Haasio Kristiina⁴,Tiirola Terttu²,Saikku Pekka¹⁵,Leinonen Maija¹

Affiliation:

1. National Public Health Institute, Department of Viral Diseases and Immunology, Oulu, Finland

2. National Public Health Institute, Department of Molecular Medicine, Helsinki, Finland

3. Department of Public Health, University of Helsinki, Helsinki, Finland

4. Orion Pharma, Espoo, Finland

5. Department of Medical Microbiology, University of Oulu, Oulu, Finland

Abstract

ABSTRACT The effects of simvastatin treatment on Chlamydia pneumoniae lung infection, inflammation, and serum lipids in mouse model were studied. Simvastatin decreased viable chlamydial counts and increased inflammatory cell infiltrates in the lung tissue, suggesting that simvastatin treatment had both antichlamydial and immunomodulatory effects during an acute C. pneumoniae infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.9.3959-3962.2005

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