Discriminating Lyme Neuroborreliosis from Other Neuroinflammatory Diseases by Levels of CXCL13 in Cerebrospinal Fluid-Reference-Cited by-同舟云学术

Discriminating Lyme Neuroborreliosis from Other Neuroinflammatory Diseases by Levels of CXCL13 in Cerebrospinal Fluid

Published:2011-05 Issue:5 Volume:49 Page:2027-2030
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

van Burgel N. D.¹,Bakels F.²,Kroes A. C. M.¹,van Dam A. P.³

Affiliation:

1. Department of Medical Microbiology, Centre of Infectious Diseases, Leiden University Medical Centre, P.O. Box 9600 RC, Leiden, Netherlands

2. Department of Neurology, Leiden University Medical Centre, P.O. Box 9600 RC, Leiden, Netherlands

3. Department of Medical Microbiology, OLVG Hospital, P.O. Box 95500, 1090 HM Amsterdam, Netherlands

Abstract

ABSTRACT CXCL13 in cerebrospinal fluid (CSF) could be an important component for diagnosing Lyme neuroborreliosis (LNB). Levels of intrathecal CXCL13 were determined for 58 LNB patients and 210 controls; sensitivity was 88% and specificity was 89% (cutoff, 250 pg of CXCL13/ml of CSF). Elevated levels of CXCL13 can aid in the diagnosis of LNB, but levels should be interpreted with care.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00084-11

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