Inhibition of Host Deoxyribonucleic Acid Synthesis by T4 Bacteriophage in the Absence of Protein Synthesis

Author:

Duckworth Donna Hardy1

Affiliation:

1. Department of Microbiology, University of Virginia, Charlottesville, Virginia 22901

Abstract

The requirement for phage protein synthesis for the inhibition of host deoxyribonucleic acid synthesis has been investigated by using a phage mutant unable to catalyze the production of any phage deoxyribonucleic acid. It has been concluded that the major pathway whereby phage inhibit host syntheses requires protein synthesis. The inhibition of host syntheses by phage ghosts is not affected by inhibitors of protein synthesis.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference18 articles.

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2. The synthesis of bacterial viruses. I. The synthesis of nucleic acid and protein in E. coli B infected with T2r+ bacteriophage;Cohen S. S.;J. Biol. Chem.,1948

3. Cohen S. S. 1968. Virus induced enzymes. Columbia University Press New York.

4. Dube S. K. and P. S. Rudland. 1970. Control of translation by T4 phage: altered binding of disfavored messengers. Nature (London) 226:820-823.

5. The metabolism of T4 phage ghostinfected cells. 1. Macromolecular synthesis and the transport of nucleic acid and protein precursors;Duckworth D. H.;Virology,1970

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