Affiliation:
1. Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721.
Abstract
We describe novel mutants of herpes simplex virus which are resistant to aphidicolin. Their mutant phenotypes suggest that they encode DNA polymerases with altered substrate recognition. This conclusion is based on their abnormal sensitivity to polymerase inhibitors and to the abnormal mutation rates exhibited by two of the mutants.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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