TroR Negatively Regulates the TroABCD System and Is Required for Resistance to Metal Toxicity and Virulence in Streptococcus suis-Reference-Cited by-同舟云学术

TroR Negatively Regulates the TroABCD System and Is Required for Resistance to Metal Toxicity and Virulence in Streptococcus suis

Published:2021-09-28 Issue:20 Volume:87 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Zheng Chengkun¹²,Wei Man¹²,Qiu Jun¹²,Jia Mengdie¹²,Zhou Xiaohui³^ORCID,Jiao Xinan¹²⁴

Affiliation:

1. Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, China

2. Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, China

3. Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, Connecticut, USA

4. Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-food Safety and Quality, the Ministry of Agriculture of China, Yangzhou University, Yangzhou, China

Abstract

Metals are essential nutrients for life; however, the accumulation of excess metals in cells can be toxic to bacteria. In the present study, we identified a metalloregulator, TroR, in Streptococcus suis , which is an emerging zoonotic pathogen.

Funder

Postdoctoral funding

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.01375-21

Reference81 articles.

1. Metal ions in biological catalysis: from enzyme databases to general principles

2. Structural insights into protein–metal ion partnerships

3. Metals in infectious diseases and nutritional immunity