Affiliation:
1. Department of Internal Medicine, University of Michigan, Ann Arbor 48109.
Abstract
Lethal enterococcal peritonitis in mice was used to compare trimethoprim-sulfamethoxazole (TMP-SMX) therapy with ampicillin therapy. Peritoneal fluid showed a 10(3)-CFU decrease in enterococci with ampicillin compared with TMP-SMX. Mortality of the untreated mice was 100%, compared with 40% for ampicillin and 95% for TMP-SMX, despite adequately measured levels in serum and peritoneal fluid.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference15 articles.
1. Trimethoprim, a sulfonamide potentiator;Bushby S. R. M.;Br. J. Pharmacol. Chemother.,1968
2. Susceptibility of enterococci to trimethoprim and trimethoprim-sulfamethoxazole;Crider S. R.;Antimicrob. Agents Chemother.,1985
3. Gollapudi S. V. S. A. Gupta H. Thadepalli and A. Perez. 1988. 1802 NOTES
4. In vivo v. in vitro susceptibility of enterococcus to trimethoprim-sulfamethoxazole: a pitfall;Goodhart G. L.;J. Am. Med. Assoc.,1984
5. The enterococcus: "putting the bug in our ears;Hoffman S. A.;Ann. Intern. Med.,1987
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