Affiliation:
1. Cleveland Clinic Foundation, Ohio 44195-5140.
Abstract
The activity of sparfloxacin (CI-978; AT-4140) was compared with those of ofloxacin and ciprofloxacin against clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis. All 10 ciprofloxacin-resistant staphylococci had reduced susceptibility to sparfloxacin and ofloxacin. Against 105 ciprofloxacin-susceptible strains of S. aureus, the sparfloxacin MIC for 90% of strains tested was at least fourfold lower than those of ciprofloxacin and ofloxacin, while against 104 ciprofloxacin-susceptible strains of S. epidermidis, the MIC of sparfloxacin for 90% of strains tested was twofold lower than that of ciprofloxacin and fourfold lower than that of ofloxacin. MBCs of sparfloxacin were less than or equal to 4 x MICs. The effects of inoculum size and pH variations, as well as the presence of serum, on the MICs of sparfloxacin were minimal. Subinhibitory concentrations of sparfloxacin did reduce adherence of S. epidermidis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference5 articles.
1. In vitro activity of AT-4140 against clinical bacterial isolates;Kojima T.;Antimicrob. Agents Chemother.,1989
2. In vitro and in vivo antibacterial activities at AT-4140, a new broad-spectrum quinolone;Nakamura S.;Antimicrob. Agents Chemother.,1989
3. National Committee for Clinical Laboratory Standards. 1990. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically (2nd ed.). Approved standard M7-A2. National Committee for Clinical Laboratory Standards Villanova Pa.
4. Characteristics of adherence of coagulase-negative staphylococci exposed to subinhibitory concentrations of antibiotics;Schadow K. H.;J. Infect. Dis.,1988
5. MBCs for Staphylococcus aureus as determined by macrodilution and microdilution techniques;Shanholtzer C. J.;Antimicrob. Agents Chemother.,1984
Cited by
27 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献