CD34 + Hematopoietic Progenitor Cell Subsets Exhibit Differential Ability To Maintain Human Cytomegalovirus Latency and Persistence-Reference-Cited by-同舟云学术

CD34 + Hematopoietic Progenitor Cell Subsets Exhibit Differential Ability To Maintain Human Cytomegalovirus Latency and Persistence

Published:2021-01-13 Issue:3 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Crawford Lindsey B.¹^ORCID,Hancock Meaghan H.¹^ORCID,Struthers Hillary M.¹,Streblow Daniel N.¹,Yurochko Andrew D.²^ORCID,Caposio Patrizia¹,Goodrum Felicia D.³,Nelson Jay A.¹

Affiliation:

1. Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA

2. Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA

3. Department of Immunobiology, BIO5 Institute, University of Arizona, Tucson, Arizona, USA

Abstract

Human cytomegalovirus infection is associated with severe disease in transplant patients, and understanding how latency and reactivation occur in stem cell populations is essential to understand disease. CD34 + hematopoietic progenitor cells (HPCs) are a critical viral reservoir; however, these cells are a heterogeneous pool with donor-to-donor variation in functional, genetic, and phenotypic characteristics.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02105-20

Reference54 articles.

1. Human Cytomegalovirus Latency: Approaching the Gordian Knot

2. Aspects of Human Cytomegalovirus Latency and Reactivation

3. Cytomegalovirus