An Alternative Animal Model for Comparison of Treatments for Cryptococcal Meningitis-Reference-Cited by-同舟云学术

An Alternative Animal Model for Comparison of Treatments for Cryptococcal Meningitis

Published:1999-02 Issue:2 Volume:43 Page:413-414
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Najvar Laura K.¹,Bocanegra Rosie¹,Graybill John R.²¹

Affiliation:

1. University of Texas Health Science Center,1 San Antonio, Texas

2. Veterans Administration Hospital2 and

Abstract

ABSTRACT Weanling outbred rats were infected with Cryptococcus neoformans by direct percranial puncture and inoculation into the cranium. A lethal infection ensued. Treatment with LY295337, a depsipeptide with antifungal activity, was effective in prolonging survival and reducing fungal counts in brain tissue. Weanling rats are an acceptable model for the study of central nervous system infection with C. neoformans .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.2.413

Reference15 articles.

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