In Vitro Activities of Benflumetol against 158 Senegalese Isolates of Plasmodium falciparum in Comparison with Those of Standard Antimalarial Drugs-Reference-Cited by-同舟云学术

In Vitro Activities of Benflumetol against 158 Senegalese Isolates of Plasmodium falciparum in Comparison with Those of Standard Antimalarial Drugs

Published:1999-02 Issue:2 Volume:43 Page:418-420
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pradines Bruno¹,Tall Adama²,Fusai Thierry¹,Spiegel Andre²,Hienne Remi¹,Rogier Christophe¹,Trape Jean Francois³,Le Bras Jacques⁴,Parzy Daniel¹

Affiliation:

1. Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Le Pharo, Marseille,1 and

2. Service d’Epidémiologie, Institut Pasteur,2 and

3. Laboratoire de Paludologie, ORSTOM,3 Dakar, Sénégal

4. Centre National de Référence de la Chimiosensibilité du Paludisme, Hôpital Bichat, Paris,4 France, and

Abstract

ABSTRACT The 50% inhibitory concentration (IC 50 s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates ( P < 0.025). No correlation or weak correlations in the responses to benflumetol and pyrimethamine, chloroquine, amodiaquine, artemether, quinine, and pyronaridine were observed, and these correlations are insufficient to suggest cross-resistance. Benflumetol may be an important alternative drug for the treatment of chloroquine-resistant malaria.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.2.418

Reference21 articles.

1. In Vitro Activity of Lumefantrine (Benflumetol) against Clinical Isolates of Plasmodium falciparum in Yaoundé, Cameroon

2. An assessment of drug-haematin as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials.;Dorn A.;Biochem. Pharmacol.,1998

3. Antimalarial schizonticides: ferriprotoporphyrin IX interaction hypothesis.;Fitch C. D.;Parasitol. Today,1986

4. Efficacy and safety of CGP 56697 (artemether and benflumetol) compared with chloroquine to treat acute malaria in Tanzanian children aged 1–5 years.;Hatz C.;Trop. Med. Int. Health,1998

5. Quinine resistant falciparum malaria acquired in East Africa.;Jelinek T.;Trop. Med. Parasitol.,1995

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