Significant Role of Interleukin-8 in Pathogenesis of Pulmonary Disease Due to Mycoplasma pneumoniae Infection

Author:

Narita Mitsuo1,Tanaka Hiroshi2,Yamada Satoshi3,Abe Shosaku2,Ariga Tadashi4,Sakiyama Yukio4

Affiliation:

1. Department of Pediatrics, Sapporo Tetsudo (JR) Hospital, Chuo-ku, Sapporo 060-0033,1

2. Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556,2

3. Department of Pediatrics, Health Sciences University of Hokkaido, Kita-ku, Sapporo 002-8072,3 and

4. Department of Gene Therapy, Hokkaido University School of Medicine, Kita-ku, Sapporo 060-8638,4 Japan

Abstract

ABSTRACT We found elevated levels of interleukin-8 in pleural fluid samples from patients with pleural effusion and with a sustained fibrotic change of the lung due to Mycoplasma pneumoniae infection. This result suggests a critical role of interleukin-8 in the pathogenesis of a certain type of pulmonary disease caused by M. pneumoniae .

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

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