Role of Porins in the Susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to Aldehyde-Based Disinfectants and Drugs-Reference-Cited by-同舟云学术

Role of Porins in the Susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to Aldehyde-Based Disinfectants and Drugs

Published:2009-09 Issue:9 Volume:53 Page:4015-4018
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Svetlíková Zuzana¹²,Škovierová Henrieta¹,Niederweis Michael³,Gaillard Jean-Louis⁴⁵,McDonnell Gerald⁶,Jackson Mary¹

Affiliation:

1. Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682

2. Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina CH-1, 84215 Bratislava, Slovak Republic

3. Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, Alabama 35294

4. Laboratoire de Microbiologie, Hôpital Ambroise Paré (Assistance Publique—Hôpitaux de Paris), F-92104 Boulogne Cedex, France

5. EA 3647, Faculté de Médecine de Paris-Ile de France-Ouest, Université de Versailles Saint-Quentin-en-Yvelines, F-92380 Garches, France

6. STERIS Limited, Jays Close, Basingstoke, England RG21 3DP

Abstract

ABSTRACT Nosocomial outbreaks attributable to glutaraldehyde-resistant, rapidly growing mycobacteria are increasing. Here, evidence is provided that defects in porin expression dramatically increase the resistance of Mycobacterium smegmatis and Mycobacterium chelonae to glutaraldehyde and another aldehyde disinfectant, ortho -phthalaldehyde. Since defects in porin activity also dramatically increased the resistance of M. chelonae to drugs, there is thus some concern that the widespread use of glutaraldehyde and ortho -phthalaldehyde in clinical settings may select for drug-resistant bacteria.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00590-09

Reference33 articles.

1. Achouak, W., T. Heulin, and J.-M. Pagès. 2001. Multiple facets of bacterial porins. FEMS Microbiol. Lett.199:1-7.

2. Inactivation of lsr2 Results in a Hypermotile Phenotype in Mycobacterium smegmatis

3. Brennan, P. J., and H. Nikaido. 1995. The envelope of mycobacteria. Annu. Rev. Biochem.64:29-63.

4. Chroneou, A., S. K. Zimmerman, S. Cook, S. Willey, J. Eyre-Kelly, N. Zias, D. S. Shapiro, J. F. Beamis, and D. E. Craven. 2008. Molecular typing of Mycobacterium chelonae isolates from a pseudo-outbreak involving an automated bronchoscope washer. Infect. Control Hosp. Epidemiol.29:1088-1090.

5. Daffé, M., and P. Draper. 1998. The envelope layers of mycobacteria with reference to their pathogenicity. Adv. Microb. Physiol.39:131-203.

Cited by 61 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Insights Into Laparoscopic Port Site Complications: A Comprehensive Review;Cureus;2024-06-28

2. Rapidly growing mycobacteria;Molecular Medical Microbiology;2024

3. Prevalence of Multidrug Resistance Efflux Pumps (MDREPs) in Environmental Communities;Microbial Diversity in the Genomic Era;2024

4. Disinfectants and antiseptics: mechanisms of action and resistance;Nature Reviews Microbiology;2023-08-30

5. Current Understanding of Potential Linkages between Biocide Tolerance and Antibiotic Cross-Resistance;Microorganisms;2023-08-03