Inactivation of the Phosphoenolpyruvate-Dependent Phosphotransferase System in Various Species of Bacteria by Vinylglycolic Acid

Author:

Snyder Mark A.1,Kaczorowski Gregory J.1,Barnes Eugene M.1,Walsh Christopher2

Affiliation:

1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77025

2. Department of Chemistry Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Abstract

The alkenoic hydroxyacid 2-hydroxy-3-butenoic acid (vinylglycolate) specifically inhibited the phosphotransferase system in a variety of bacteria while not affecting respiration-coupled transport systems.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference9 articles.

1. Respiration-coupled glucose transport in membrane vesicles from Azotobacter vinelandii;Barnes E. M.;Arch. Biochem. Biophys.,1972

2. Bacterial membranes;Kaback H. R.;Methods Enzymol.,1971

3. Transport in isolated bacterial membrane vesicles;Kaback H. R.;Methods Enzymol.,1974

4. Mechanism of assembly of the outer membrane of Salmonella typhimurium;Osborn M. J.;J. Biol. Chem.,1972

5. Vinylglycolate resistance in Escherichia coli;Shaw L.;J. Bacteriol.,1975

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