Polyvalent Protein Adhesin MEFA-II Induces Functional Antibodies against Enterotoxigenic Escherichia coli (ETEC) Adhesins CS7, CS12, CS14, CS17, and CS21 and Heat-Stable Toxin (STa)-Reference-Cited by-同舟云学术

Polyvalent Protein Adhesin MEFA-II Induces Functional Antibodies against Enterotoxigenic Escherichia coli (ETEC) Adhesins CS7, CS12, CS14, CS17, and CS21 and Heat-Stable Toxin (STa)

Published:2023-06-28 Issue:6 Volume:89 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Upadhyay Ipshita¹,Parvej Shafiullah M. D.¹,Li Siqi¹,Lauder Kathryn L.¹,Shen Yiyang¹,Zhang Weiping¹^ORCID

Affiliation:

1. Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Abstract

An effective vaccine is lacking against ETEC, a primary cause of children’s diarrhea and traveler’s diarrhea and a threat to global health. The key challenge in ETEC vaccine development is that ETEC bacteria express heterogeneous virulence determinants (>25 adhesins and two toxins).

Funder

NIH

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.00683-23

Reference37 articles.

1. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

2. Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study

3. Etiology of travellers’ diarrhea

4. Vaccines against Shigella and enterotoxigenic Escherichia coli : A summary of the 2016 VASE Conference

5. The role of bacterial vaccines in the fight against antimicrobial resistance: an analysis of the preclinical and clinical development pipeline

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1. MecVax supplemented with CFA MEFA-II induces functional antibodies against 12 adhesins (CFA/I, CS1–CS7, CS12, CS14, CS17, and CS21) and 2 toxins (STa, LT) of enterotoxigenic Escherichia coli (ETEC);Microbiology Spectrum;2024-04-02

2. Colonization factors of human and animal-specific enterotoxigenic Escherichia coli (ETEC);Trends in Microbiology;2023-12

3. A Polyvalent Adhesin–Toxoid Multiepitope-Fusion-Antigen-Induced Functional Antibodies against Five Enterotoxigenic Escherichia coli Adhesins (CS7, CS12, CS14, CS17, and CS21) but Not Enterotoxins (LT and STa);Microorganisms;2023-10-01