Affiliation:
1. Department of Chemistry, University of Maryland, College Park, Maryland 20742
Abstract
A resting culture of
Rhizopus arrhizus
(ATCC 11145) transformed verrucarin A into 16-hydroxyverrucarin A, whereas
R. arrhizus
transformed verrucarin B into a mixture of 16-hydroxyverrucarin B and 3′-hydroxyverrucarin A. Relative to verrucarins A and B, the 16-hydroxy derivatives showed marked increases in activity, as tested in vivo against P388 mouse leukemia.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
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