Genetic Analysis of an Ambler Class A Extended-Spectrum Beta-Lactamase from Capnocytophaga ochracea-Reference-Cited by-同舟云学术

Genetic Analysis of an Ambler Class A Extended-Spectrum Beta-Lactamase from Capnocytophaga ochracea

Published:2004-02 Issue:2 Volume:42 Page:888-890
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Jolivet-Gougeon Anne¹,Tamanai-Shacoori Zohreh²,Desbordes Laurent¹,Burggraeve Nathalie²,Cormier Michel¹,Bonnaure-Mallet Martine²

Affiliation:

1. Laboratoire de Microbiologie Pharmaceutique, UPRES-EA 1254, Université de Rennes 1, 35043 Rennes

2. Equipe de Biologie Buccale, UPRES-EA 1256, UFR Odontologie, Université de Rennes 1, 35000 Rennes, France

Abstract

ABSTRACT A beta-lactamase gene ( cfxA3 , 966 bp) was isolated from a beta-lactam-resistant Capnocytophaga ochracea clinical isolate and amplified using primers from the cfxA gene of Bacteroides vulgatus . The MICs of third-generation cephalosporins were much higher than those of the transconjugant Escherichia coli strain. The deduced protein sequence, by comparison with CfxA2 of Prevotella intermedia , had a Y239D substitution and possessed the characteristics of a class A, group 2e beta-lactamase.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.42.2.888-890.2004

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