Different Viral Rebound following Discontinuation of Antiretroviral Therapy in Cases of Infection with Viruses Carrying L74V or Thymidine-Associated Mutations-Reference-Cited by-同舟云学术

Different Viral Rebound following Discontinuation of Antiretroviral Therapy in Cases of Infection with Viruses Carrying L74V or Thymidine-Associated Mutations

Published:2004-02 Issue:2 Volume:42 Page:862-866
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

de Mendoza Carmen¹,Paxinos Ellen²,Barreiro Pablo¹,Camino Nuria¹,Núñez Marina¹,Soriano Vincent¹

Affiliation:

1. Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain

2. ViroLogic, South San Francisco, California

Abstract

ABSTRACT A total of 76 patients discontinued treatment with didanosine plus hydroxyurea after 1 year of maintenance therapy. The greatest human immunodeficiency virus (HIV)-RNA rebounds were seen in 10 patients harboring an L74V mutation, and the presence of viruses with this mutation rapidly waned. In contrast, viral rebounds were significantly less pronounced ( P < 0.01) in 12 subjects harboring thymidine-associated mutations; these mutations persisted in all instances. Thus, selection of an L74V mutation during didanosine therapy may compromise HIV replication in vivo.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.42.2.862-866.2004

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