Characterization of bactericidal activity of clindamycin against Bacteroides fragilis via kill curve methods-Reference-Cited by-同舟云学术

Characterization of bactericidal activity of clindamycin against Bacteroides fragilis via kill curve methods

Published:1996-08 Issue:8 Volume:40 Page:1941-1944
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Klepser M E¹,Banevicius M A¹,Quintiliani R¹,Nightingale C H¹

Affiliation:

1. Department of Pharmacy, Hartford Hospital, Connecticut 06102, USA. michael-klepser@uiowa.edu

Abstract

Kill curves were determined for five isolates of Bacteroides fragilis with clindamycin at concentrations equal to the MIC or to 4, 16, and 64 times the MIC. Examination of plots of log CFU per milliliter versus time revealed no association between the clindamycin concentration and the rate and extent of the bactericidal activity against B. fragilis at or below 64 times the MIC.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.40.8.1941

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