Penetration of doxycycline into cerebrospinal fluid in patients treated for suspected Lyme neuroborreliosis

Author:

Dotevall L1,Hagberg L1

Affiliation:

1. Department of Infectious Diseases, University of Göteborg, Sweden.

Abstract

Twelve patients were treated orally with 100 mg of doxycycline twice a day (b.i.d.) and 10 patients were treated with 200 mg b.i.d. for suspected tick-borne neuroborreliosis (Lyme borreliosis). At 5 to 8 days after the start of therapy, the mean concentrations in serum were 4.7 micrograms/ml for the doxycycline dose of 100 mg b.i.d. and 7.5 micrograms/ml for 200 mg b.i.d., 2 to 3 h after the last drug administration. The corresponding levels for cerebrospinal fluid were 0.6 and 1.1 micrograms/ml. Since a doxycycline concentration in cerebrospinal fluid above the estimated MIC for Borrelia burgdorferi (0.6 to 0.7 microgram/ml) is wanted in patients treated for severe neuroborreliosis, the higher dose is preferable.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference13 articles.

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2. Relation between lipophilicity and pharmacological behavior of minocycline, doxycycline, tetracycline, and oxytetracycline in dogs;Barza M.;Antimicrob. Agents Chemother.,1975

3. Dattwyler R. J. D. J. Volkman J. J. Halperin and B. J. Luft. 1988. Treatment of late Lyme borreliosis-randomized comparison of ceftriaxone and penicillin. Lancet i:1191-1194.

4. The use of doxycycline in nervous system Borrelia burgdorferi infection;Dotevall L.;Scand. J. Infect. Dis.,1988

5. Evaluation of a micromethod for determination of antibiotic concentrations in plasma;Jalling B.;Eur. J. Clin. Pharmacol.,1972

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