Specificity of Acquired Resistance Produced by Immunization with Listeria monocytogenes and Listeria Fractions

Author:

Coppel Suzanne1,Youmans Guy P.1

Affiliation:

1. Department of Microbiology, Northwestern University Medical School, Chicago, Illinois 60611

Abstract

Mice were immunized with 1.0 mg of an attenuated strain of Listeria monocytogenes to determine the period of protection afforded by this strain when the mice were challenged intravenously with 5 MLD of listeria. Protection appeared 2 days after immunization and was still apparent 4 weeks after immunization. If the challenge dose was decreased to 1 MLD, protection was apparent at 10 weeks. Mice immunized with a comparable dose of mycobacterial cells and challenged intravenously with 1 MLD of listeria showed no protection at 10 weeks. The magnitude of the immune response to listeria challenge was not increased in mice immunized with the same virulent strain as that used for challenge. It was also found that resistance to listeria challenge appeared early after listeria immunization if the immunizing dose was large. As the immunizing dose was decreased and the challenge dose increased, resistance appeared later. Listeria killed by heat or ultraviolet irradiation, living but nonmultiplying streptomycin-dependent listeria, or listeria ribosomal fraction gave no protection against listeria challenge. The magnitude of the immune responses after listeria immunization to listeria challenge and to mycobacteria challenge were compared. It was found that protection after listeria challenge was of longer duration. In addition, a 100-fold larger vaccinating dose was required to give comparable protection against tuberculous infection.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference20 articles.

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2. Asahi 0. 1962. Present situation of listeria vaccine for animal use p. 49-56. In M. L. Gray (ed.) 2nd symposium on listeric infection. Montana State Coilege Bozeman. J. BAcrERioL.

3. Mechanisms of acquired resistance in mouse typhoid;Blanden R. V.;J. Exptl. Med.,1966

4. Specificity of acquired resistance produced by immunization with mycobacterial cells and mycobacterial fractions;Coppel S.;J. Bacteriol.,1969

5. Specificity of the anemnestic response produced by Listerla monocytogenes or Mycobacterium tuberculosis to challenge with Listeria monocytogenes;Coppel S.;J. Bacteriol.,1969

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