Isolation of a New Soluble Antigen from the Yeast Phase of Histoplasma capsulatum-Reference-Cited by-同舟云学术

Isolation of a New Soluble Antigen from the Yeast Phase of Histoplasma capsulatum

Published:1972-11 Issue:5 Volume:24 Page:841-843
ISSN:0003-6919
Container-title:Applied Microbiology
language:en
Short-container-title:Appl Microbiol

Author:

Reeves Michael W.¹,Pine Leo¹,Kaufman Leo¹,McLaughlin David¹

Affiliation:

1. Research and Development Unit, Biological Reagents Section and Fungus Immunology Unit, Mycology Section, Center for Disease Control, Health Services and Mental Health Administration, Atlanta, Georgia 30333

Abstract

A method is described by which a soluble antigen was prepared from the yeast phase of Histoplasma capsulatum . This soluble preparation had a specificity greater than that of whole-cell yeast-phase antigens. In complement fixation tests with sera from human cases of histoplasmosis, blastomycosis, and coccidioidomycosis, the soluble antigen reacted in 12.1% of 141 tests with heterologous sera, whereas conventional whole-cell yeast antigens reacted in 47.3% of 91 tests with heterologous sera. The reactivities of the two types of antigens with homologous sera were essentially the same.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://journals.asm.org/doi/pdf/10.1128/am.24.5.841-843.1972

Reference13 articles.

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3. Tests of immunity in histoplasmosis;Furcolow M. L.;N. Engl. J. Med.,1963

4. Complement fixing cross reactivity between Histoplasma capsulatum and certain form-related aleuriosporic hyphomycetes;Garrison R. G.;Mycopathol. Mycolog. Appl.,1967

5. Serology of systemic fungus diseases;Kaufman L.;Pub. Health Rep.,1966

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1. Immunobiological activity of recombinant H antigen from Histoplasma capsulatum;Infection and Immunity;1995-08

2. Blastomyces dermatitidis antigen-induced lymphocytes reactivity in human blastomycosis;Infection and Immunity;1981-08

3. H and M antigens of Histoplasma capsulatum: preparation of antisera and location of these antigens in yeast-phase cells;Infection and Immunity;1976-09

4. Characterization and Evaluation of a Soluble Antigen Complex Prepared from the Yeast Phase of Histoplasma capsulatum;Infection and Immunity;1974-06