Enhanced Killing of Triple-Negative Breast Cancer Cells by Reassortant Reovirus and Topoisomerase Inhibitors

Author:

Rodríguez Stewart Roxana M.12,Berry Jameson T. L.12,Berger Angela K.23,Yoon Sung Bo1,Hirsch Aspen L.23,Guberman Jaime A.1,Patel Nirav B.4,Tharp Gregory K.4,Bosinger Steven E.4,Mainou Bernardo A.23ORCID

Affiliation:

1. Emory University, Atlanta, Georgia, USA

2. Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

3. Children’s Healthcare of Atlanta, Atlanta, Georgia, USA

4. Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, Georgia, USA

Abstract

Patients afflicted by triple-negative breast cancer have decreased survival and limited therapeutic options. Reovirus infection results in cell death of a variety of cancers, but it is unknown if different reovirus types lead to triple-negative breast cancer cell death. In this study, we generated two novel reoviruses that more efficiently infect and kill triple-negative breast cancer cells. We show that infection in the presence of DNA-damaging agents enhances infection and triple-negative breast cancer cell killing by reovirus. These data suggest that a combination of a genetically engineered oncolytic reovirus and topoisomerase inhibitors may provide a potent therapeutic option for patients afflicted with triple-negative breast cancer.

Funder

HHS | National Institutes of Health

American Cancer Society

Children's Healthcare of Atlanta

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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