Mutations in the Neuraminidase-Like Protein of Bat Influenza H18N11 Virus Enhance Virus Replication in Mammalian Cells, Mice, and Ferrets-Reference-Cited by-同舟云学术

Mutations in the Neuraminidase-Like Protein of Bat Influenza H18N11 Virus Enhance Virus Replication in Mammalian Cells, Mice, and Ferrets

Published:2020-02-14 Issue:5 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zhong Gongxun¹,Fan Shufang¹,Hatta Masato¹,Nakatsu Sumiho²,Walters Kevin B.¹,Lopes Tiago J. S.¹,Wang Jessica I-Hsuan²,Ozawa Makoto¹,Karasin Alexander¹,Li Yan³,Tong Suxiang³,Donis Ruben O.⁴,Neumann Gabriele¹,Kawaoka Yoshihiro¹²

Affiliation:

1. Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA

2. Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

3. Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, Georgia, USA

4. Influenza Division, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, Georgia, USA

Abstract

Bats are reservoirs for several severe zoonotic pathogens. The genomes of influenza A viruses of the H17N10 and H18N11 subtypes have been identified in bats, but no live virus has been isolated. The characterization of artificially generated bat influenza H18N11 virus in mammalian cell lines and animal models revealed that this virus can acquire mammal-adapting mutations that may increase its zoonotic potential; however, the wild-type and mutant viruses did not replicate to high titers in all infected animals.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01416-19

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