Multiple Respiratory Syncytial Virus (RSV) Strains Infecting HEp-2 and A549 Cells Reveal Cell Line-Dependent Differences in Resistance to RSV Infection-Reference-Cited by-同舟云学术

Multiple Respiratory Syncytial Virus (RSV) Strains Infecting HEp-2 and A549 Cells Reveal Cell Line-Dependent Differences in Resistance to RSV Infection

Published:2022-04-13 Issue:7 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Rajan Anubama¹,Piedra Felipe-Andrés¹,Aideyan Letisha¹,McBride Trevor¹,Robertson Matthew²³,Johnson Hannah L.⁴,Aloisio Gina Marie¹,Henke David¹,Coarfa Cristian²³,Stossi Fabio²⁴,Menon Vipin Kumar⁵,Doddapaneni Harshavardhan⁵,Muzny Donna Marie⁵,Javornik Cregeen Sara Joan¹,Hoffman Kristi Louise¹,Petrosino Joseph¹,Gibbs Richard A.⁵,Avadhanula Vasanthi¹,Piedra Pedro A.¹⁶^ORCID

Affiliation:

1. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

2. Molecular and Cell Biology-Mol. Regulation, Baylor College of Medicine, Houston, Texas, USA

3. Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA

4. Integrated Microscopy Core at the Gulf Coast Consortium Center for Advanced Microscopy and Image Informatics, Baylor College of Medicine, Houston, Texas, USA

5. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA

6. Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA

Abstract

Infection with the respiratory syncytial virus (RSV) early in life is essentially guaranteed and can lead to severe disease. Most RSV studies have involved either of two historic RSV/A strains infecting one of two cell lines, HEp-2 or A549 cells.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01904-21

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2. Respiratory Syncytial Virus whole-genome sequencing identifies convergent evolution of sequence duplication in the C-terminus of the G gene

3. Functional Analysis of the 60-Nucleotide Duplication in the Respiratory Syncytial Virus Buenos Aires Strain Attachment Glycoprotein