Antiphagocytic Effect of Slime from a Mucoid Strain of Pseudomonas aeruginosa

Author:

Schwarzmann Stephen1,Boring John R.1

Affiliation:

1. Departments of Preventive Medicine and Medicine, Emory University School of Medicine, Atlanta, Georgia 30303

Abstract

Mucoid strains of Pseudomonas aeruginosa produce a viscid slime when grown on the surface of agar media. These strains are known to colonize persistently the tracheobronchial tree of children with cystic fibrosis. Colonization may result from inhibition of phagocytosis due to slime produced by the organism. Slime separated from one mucoid strain was examined to determine whether it possessed antiphagocytic activity in vitro. Cells of P. aeruginosa, Escherichia coli , and Staphylococcus aureus were rapidly phagocytized by rabbit polymorphonuclear leukocytes when mixtures were rotated for 2 hr at 37 C in the absence of slime. The addition of relatively small amounts of slime to bacteria and leukocytes inhibited phagocytosis as measured by phagocytic killing of the organisms. Inhibition was found to be most complete with P. aeruginosa .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference16 articles.

1. Serogroups of Pseudomonas aeruginosa and the immune response of patients with cystic fibrosis;Diaz F.;J. Infec. Dis.,1970

2. An atypical Pseudomonas aeruginosa associated with cystic fibrosis of the pancreas;Doggett R. C.;J. Pediat.,1966

3. Comparison of some properties of Pseudomonas aeruginosa isolated from infections in persons with and without cysticfibrosis;Doggett R. G.;J. Bacteriol.,1964

4. Edwards P. R. and W. H. Ewing. 1964. Identification of Enterobacteriaceae. Burgess Publishing Company Minneapolis.

5. Surveillance bacteriologique de l'expectoration de 22 malades atteints de mucoviscidose;Feigelson J.;Arch. Fr. Pediat.,1967

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