High-Level Biosynthesis of the Anteiso-C 17 Isoform of the Antibiotic Mycosubtilin in Bacillus subtilis and Characterization of Its Candidacidal Activity-Reference-Cited by-同舟云学术

High-Level Biosynthesis of the Anteiso-C 17 Isoform of the Antibiotic Mycosubtilin in Bacillus subtilis and Characterization of Its Candidacidal Activity

Published:2009-07 Issue:13 Volume:75 Page:4636-4640
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Fickers Patrick¹,Guez Jean-Sébastien²,Damblon Christian³,Leclère Valérie²,Béchet Max²,Jacques Philippe²,Joris Bernard¹

Affiliation:

1. Centre d'Ingénierie des Protéines, Université de Liège, Institut de Chimie, Bat B6, B-4000 Liège, Belgium

2. Laboratoire de Procédés Biologiques, Génie Enzymatique et Microbien (ProBioGEM, UPRES EA 1026), Polytech'Lille, Université des Sciences et Technologies de Lille, F-59655 Villeneuve d'Ascq Cedex, France

3. Chimie Biologique Structurale, Université de Liège, Institut de Chimie, Bat B6, B-4000 Liège, Belgium

Abstract

ABSTRACT High-level production (880 mg liter −1 ) and isolation of the anteiso-C 17 isoform of the lipopeptide mycosubtilin produced by a genetically engineered Bacillus subtilis strain are reported. Antifungal activity of this isoform, as determined via culture and fluorometric and cell leakage assays, suggests its potential therapeutic use as an antifungal agent, in particular against Candida spp.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00548-09

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