Affiliation:
1. Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel,
2. National Center of Infection Control, Ministry of Health, Tel Aviv, Israel
Abstract
ABSTRACT
Transmission of antibiotic resistance genes may be mediated by a variety of molecular mechanisms, from mobility of small genetic elements to clonal spread. Since 1997, the carbapenem-hydrolyzing enzyme
Klebsiella pneumoniae
carbapenemase (KPC) has spread in the United States and across the world, mainly via a single
K. pneumoniae
clone, sequence type 258. By tracking the trail of dissemination of the
bla
KPC
gene inside their institution, Mathers et al. (mBio 2:e00204–11, 2011) have shown evidence of the ability of this gene to spread by several modes, including plasmid transfer and clonal spread. The ever-evolving modes of transmission of resistance genes challenge our ability to detect, track, and eventually control the spread of what has become a major threat to hospitalized patients worldwide.
Publisher
American Society for Microbiology
Cited by
11 articles.
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