Disulfiram inhibits the in vitro growth of methicillin-resistant staphylococcus aureus

Author:

Phillips M1,Malloy G1,Nedunchezian D1,Lukrec A1,Howard R G1

Affiliation:

1. Department of Medicine, St. Vincent's Medical Center of Richmond, Staten Island, New York 10310.

Abstract

Several antibiotics have disulfiram-like effects; we evaluated disulfiram for its antibiotic-like effects. Disulfiram inhibited the in vitro growth of methicillin-resistant Staphylococcus aureus, with an MIC of 1.33 micrograms/ml, but was not effective against members of the family Enterobacteriaceae or Pseudomonas species.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference26 articles.

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5. Diphosphopyridine nucleotide-linked aldehyde dehydrogenase III sulfhydryl characteristics of the enzyme;Deitrich R. A.;Arch. Biochem. Biophys.,1967

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