Affiliation:
1. Department of Molecular Microbiology1 and
2. Histopathology Department, St. Thomas' Hospital, London SE1 7EH,2United Kingdom
3. Public Health Laboratory Service,3 Southampton General Hospital, Southampton SO16 6YD, and
Abstract
ABSTRACT
The purpose of this study was to determine if
Neisseria gonorrhoeae; Chlamydia trachomatis
; herpes simplex virus; cytomegalovirus; Epstein-Barr virus; human herpesviruses 6, 7, and 8; or adeno-associated virus influenced the production of cervical intraepithelial neoplasia. Two hundred thirty-one cervical smear samples were tested for the presence of the organisms by PCR. In addition, human papillomavirus types in the samples were determined by PCR and classified into cancer risk types of high, moderate, and low. There was no link with cervical intraepithelial neoplasia status and detection of herpes simplex virus, cytomegalovirus, Epstein-Barr virus, human herpesviruses 6 and 8, gonorrhea, or chlamydia. However, high-grade cervical intraepithelial neoplasia was found more frequently with mixed infection by moderate-risk human papillomavirus types and human herpesvirus 7 than with these papillomavirus types alone. The presence of human herpesvirus 7 may increase the oncogenic potential of moderate-risk human papillomavirus types.
Publisher
American Society for Microbiology
Cited by
20 articles.
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