Mutation of Saccharomyces cerevisiae Preventing Uptake of S -Adenosylmethionine

Abstract

A mutant has been isolated whose aberration severely restricts the ability of cells of Saccharomyces cerevisiae to take up S -adenosylmethionine. The mutation apparently also affects adenosylhomocysteine uptake, but not that of the S -adenosylmethionine moieties adenine, homocysteine, homoserine, or methionine, nor the sulfonium compound, S -methylmethionine. It is a single, chromosomal mutation whose expression is not dependent on the presence of ammonium ions.