Predicting the Disposition of the Antimalarial Drug Artesunate and Its Active Metabolite Dihydroartemisinin Using Physiologically Based Pharmacokinetic Modeling-Reference-Cited by-同舟云学术

Predicting the Disposition of the Antimalarial Drug Artesunate and Its Active Metabolite Dihydroartemisinin Using Physiologically Based Pharmacokinetic Modeling

Published:2021-02-17 Issue:3 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Arey Ryan¹,Reisfeld Brad¹²³

Affiliation:

1. School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, USA

2. Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado, USA

3. Colorado School of Public Health, Colorado State University, Fort Collins, Colorado, USA

Abstract

Artemisinin-based combination therapies (ACTs) have proven to be effective in helping to combat the global malaria epidemic. To optimally apply these drugs, information about their tissue-specific disposition is required, and one approach to predict these pharmacokinetic characteristics is physiologically based pharmacokinetic (PBPK) modeling.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02280-20

Reference51 articles.

1. World Health Organization. 2015. Guidelines for the treatment of malaria. World Health Organization, Geneva, Switzerland.

2. Clinical Pharmacology of Artemisinin-Based Combination Therapies

3. Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species

4. Pharmacokinetics of Artemisinin-Type Compounds

5. Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration

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