Lactoferrin Is Broadly Active against Yeasts and Highly Synergistic with Amphotericin B-Reference-Cited by-同舟云学术

Lactoferrin Is Broadly Active against Yeasts and Highly Synergistic with Amphotericin B

Published:2020-04-21 Issue:5 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Fernandes Kenya E.¹^ORCID,Weeks Kerry²,Carter Dee A.¹^ORCID

Affiliation:

1. School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia

2. NSW Health Pathology, Microbiology Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

Abstract

Lactoferrin (LF) is a multifunctional milk protein with antimicrobial activity against a range of pathogens. While numerous studies report that LF is active against fungi, there are considerable differences in the level of antifungal activity and the capacity of LF to interact with other drugs. Here we undertook a comprehensive evaluation of the antifungal spectrum of activity of three defined sources of LF across 22 yeast and 24 mold species and assessed its interactions with six widely used antifungal drugs.

Funder

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02284-19

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