Chromosome-Encoded CTX-M-3 from Kluyvera ascorbata : a Possible Origin of Plasmid-Borne CTX-M-1-Derived Cefotaximases

Author:

Rodríguez María Margarita1,Power Pablo1,Radice Marcela1,Vay Carlos2,Famiglietti Angela2,Galleni Moreno3,Ayala Juan A.4,Gutkind Gabriel1

Affiliation:

1. Cátedra de Microbiología

2. Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina

3. Centre d′Ingéniérie des Protéines, Institut de Chimie, Université de Liège, Sart Tilman, Belgium

4. Centro de Biología Molecular “Severo Ochoa,” CSIC-UAM, Campus de Cantoblanco, Madrid, Spain

Abstract

ABSTRACT A gene identical to plasmid-borne bla CTX-M-3 is present in the chromosome of one Kluyvera ascorbata strain. It is associated with a structure including an inverted repeat right and an open reading frame 477-like gene probably involved in the mobilization of bla CTX-M-3 . Two other K. ascorbata strains rendered the previously described bla KLUA-9 gene.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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