Antimicrobial and Antileishmanial Activities of Hypocrellins A and B-Reference-Cited by-同舟云学术

Antimicrobial and Antileishmanial Activities of Hypocrellins A and B

Published:2004-11 Issue:11 Volume:48 Page:4450-4452
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ma Guoyi¹,Khan Shabana I.¹,Jacob Melissa R.¹,Tekwani Babu L.¹,Li Zuqiang²,Pasco David S.¹³,Walker Larry A.¹⁴,Khan Ikhlas A.¹³

Affiliation:

1. National Center for Natural Products Research

2. Experimental Center, Yunnan University, Kunming, People's Republic of China

3. Department of Pharmacognosy

4. Department of Pharmacology, School of Pharmacy, The University of Mississippi, University, Mississippi

Abstract

ABSTRACT Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus , methicillin-resistant S. aureus , Pseudomonas aeruginosa , and Mycobacterium intracellulare . Hypocrellin B showed weak antimicrobial activities. Hypocrellin A exhibited potent antileishmanial activity, while hypocrellin B was only moderately active. These results of promising antifungal and antileishmanial activity of hypocrellin A may be useful for further structure-activity relationship and in vivo studies.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.11.4450-4452.2004

Reference21 articles.

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