Daptomycin Is Highly Efficacious against Penicillin-Resistant and Penicillin- and Quinolone-Resistant Pneumococci in Experimental Meningitis-Reference-Cited by-同舟云学术

Daptomycin Is Highly Efficacious against Penicillin-Resistant and Penicillin- and Quinolone-Resistant Pneumococci in Experimental Meningitis

Published:2004-10 Issue:10 Volume:48 Page:3928-3933
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cottagnoud Philippe¹,Pfister Marc²,Acosta Fernando³,Cottagnoud Marianne³,Flatz Lukas³,Kühn Felix³,Müller Hans-Peter¹,Stucki Armin¹

Affiliation:

1. Department of Internal Medicine, Inselspital

2. Department of Laboratory Medicine and Biopharmaceutical Sciences, University of California, San Francisco, San Francisco, California

3. Department of Internal Medicine, Spital Bern-Ziegler, Bern, Switzerland

Abstract

ABSTRACT The penetration of daptomycin, a new lipopeptide antibiotic, into inflamed meninges ranged between 4.37 and 7.53% (mean, 5.97%). Daptomycin was very efficacious in the treatment of experimental pneumococcal meningitis, producing a decrease of −1.20 ± 0.32 Δlog 10 CFU/ml · h in the bacterial titer of Streptococcus pneumoniae against a penicillin-resistant strain and of −0.97 ± 0.32 Δlog 10 CFU/ml · h against a penicillin- and quinolone-resistant strain found in cerebrospinal fluid (CSF). For both strains, daptomycin was significantly superior to the standard regimen of a combination of ceftriaxone with vancomycin, sterilizing 9 of 10 CSF samples after 4 h. In vitro, daptomycin produced highly bactericidal activity in concentrations above the MIC.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.10.3928-3933.2004

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