Effect of Heat-Treated Amphotericin B on Renal and Fungal Cytotoxicity-Reference-Cited by-同舟云学术

Effect of Heat-Treated Amphotericin B on Renal and Fungal Cytotoxicity

Published:2004-01 Issue:1 Volume:48 Page:333-336
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bartlett Karen¹,Yau Edwin²,Hartsel Scott C.³,Hamer Alison²,Tsai Gina²,Bizzotto Dan⁴,Wasan Kishor M.²

Affiliation:

1. School of Occupational and Environmental Hygiene

2. Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3

3. Department of Chemistry, University of Wisconsin—Eau Claire, Eau Claire, Wisconsin

4. Department of Chemistry, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1

Abstract

ABSTRACT The purpose of this investigation was to determine the cytotoxicity of amphotericin B (AMB; trade name Fungizone [FZ]) following the administration of FZ and a heat-treated form of FZ (HFZ) to LLC-PK 1 pig kidney cells and Cryptococcus neoformans var. gattii cells. HFZ was significantly less toxic to kidney cells than FZ at all concentrations tested. For both FZ and HFZ, the concentration range which resulted in a 50% reduction of the growth of fungal cells was 0.125 to 1 mg/ml. These findings suggest that heat treatment decreases AMB's renal cytotoxicity without modifying its antifungal activity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.1.333-336.2004

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