Prevalence of Mutations within the Quinolone Resistance-Determining Region of gyrA , gyrB , parC , and parE and Association with Antibiotic Resistance in Quinolone-Resistant Salmonella enterica

Author:

Eaves Deborah J.1,Randall Luke2,Gray Douglas T.1,Buckley Antony1,Woodward Martin J.2,White Allan P.3,Piddock Laura J. V.1

Affiliation:

1. Antimicrobial Agents Research Group, Division of Immunity and Infection

2. Department of Food and Environmental Safety, Veterinary Laboratories Agency, New Haw, Surrey

3. Statistical Advisory Service

Abstract

ABSTRACT Salmonella enterica isolates ( n = 182) were examined for mutations in the quinolone resistance-determining region of gyrA , gyrB , parC , and parE . The frequency, location, and type of GyrA substitution varied with the serovar. Mutations were found in parC that encoded Thr57-Ser, Thr66-Ile, and Ser80-Arg substitutions. Mutations in the gyrB quinolone resistance-determining region were located at codon Tyr420-Cys or Arg437-Leu. Novel mutations were also found in parE encoding Glu453-Gly, His461-Tyr, Ala498-Thr, Val512-Gly, and Ser518-Cys. Although it is counterintuitive, isolates with a mutation in both gyrA and parC were more susceptible to ciprofloxacin than were isolates with a mutation in gyrA alone.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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