Affiliation:
1. Antimicrobial Agents Research Group, Division of Immunity and Infection
2. Department of Food and Environmental Safety, Veterinary Laboratories Agency, New Haw, Surrey
3. Statistical Advisory Service
Abstract
ABSTRACT
Salmonella enterica
isolates (
n
= 182) were examined for mutations in the quinolone resistance-determining region of
gyrA
,
gyrB
,
parC
, and
parE
. The frequency, location, and type of GyrA substitution varied with the serovar. Mutations were found in
parC
that encoded Thr57-Ser, Thr66-Ile, and Ser80-Arg substitutions. Mutations in the
gyrB
quinolone resistance-determining region were located at codon Tyr420-Cys or Arg437-Leu. Novel mutations were also found in
parE
encoding Glu453-Gly, His461-Tyr, Ala498-Thr, Val512-Gly, and Ser518-Cys. Although it is counterintuitive, isolates with a mutation in both
gyrA
and
parC
were more susceptible to ciprofloxacin than were isolates with a mutation in
gyrA
alone.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
201 articles.
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