Reversal of L Phase by Slow Inactivation of Penicillin with Polyamines-Reference-Cited by-同舟云学术

Reversal of L Phase by Slow Inactivation of Penicillin with Polyamines

Published:1970-09 Issue:3 Volume:2 Page:292-297
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Lapinski E. M.¹,Flakas E. D.¹

Affiliation:

1. Clinical Laboratory Service, Veterans Administration Hospital, and Department of Medical Microbiology, University of Wisconsin School of Medicine, Madison, Wisconsin 53705

Abstract

Spermine reversal of penicillin-induced L phase of Haemophilus was found to be due to slow inactivation of penicillin by spermine. This inactivation was inhibited by sodium chloride. Cycloserine and cephalothin were also inactivated by spermine as demonstrated by reversal of L phase induced by these antibiotics. Spermine was inhibitory for growth of L phase induced by glycine. Spermidine and the diamines, putrescine and cadaverine, also interacted with penicillin, but very slowly and only at high molar ratios of polyamine to penicillin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.2.3.292-297.1970

Reference8 articles.

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2. Effects of antibiotics on induction, viability and reversion potential of L-forms of Haemophilus influenzae;Lapinski E. M.;J. Bacteriol.,1969

3. Reversal of penicillin-induced L-phase growth of Haemophilus inrfluenzae by spermine and its effects on antibiotic suspectibility;Lapinski E. M.;Infec. Immun.,1970

4. Spermine as a protective agent against osmotic lysis;Mager J.;Nature,1959

5. Neuhaus F. C. 1968. Selective inhibition of enzymes utilizing alanine in the biosynthesis of peptidoglycan p. 304-313. In G. L. Hobby (ed.) Antimicrob. Agents Chemother.- 1967.