CagA and VacA Polymorphisms Are Associated with Distinct Pathological Features in Helicobacter pylori -Infected Adults with Peptic Ulcer and Non-Peptic Ulcer Disease-Reference-Cited by-同舟云学术

CagA and VacA Polymorphisms Are Associated with Distinct Pathological Features in Helicobacter pylori -Infected Adults with Peptic Ulcer and Non-Peptic Ulcer Disease

Published:2010-06 Issue:6 Volume:48 Page:2237-2239
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Panayotopoulou Effrosini G.¹,Sgouras Dionyssios N.¹,Papadakos Konstantinos S.¹,Petraki Kalliopi¹,Breurec Sébastien²,Michopoulos Spyros³,Mantzaris Gerassimos⁴,Papatheodoridis George⁵,Mentis Andreas¹,Archimandritis Athanasios⁵

Affiliation:

1. Laboratory of Medical Microbiology, Hellenic Pasteur Institute, Athens, Greece

2. Laboratoire de Biologie Médicale, Institut Pasteur, Dakar, Senegal

3. Gastroenterology Clinic, Alexandra Hospital, Athens, Greece

4. Gastroenterology Clinic, Evangelismos Hospital, Athens, Greece

5. Second Department of Internal Medicine, Athens University School of Medicine, Athens, Greece

Abstract

ABSTRACT Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00662-10

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